DESCRIPTION :
The ANR "SMART" investigates the mechanisms of DNA double-strand break (DSB) repair, with a particular focus on homologous recombination (HR)-a critical pathway for maintaining genome integrity. DSBs arise both accidentally, such as during replication stress, and deliberately, as in meiosis where they facilitate accurate chromosome segregation. Failure to properly repair these breaks can lead to genomic instability, contributing to diseases such as cancer and neurodegenerative disorders.
"SMART" brings together an interdisciplinary expertise in molecular biology, genomics, and bioinformatics. Our goal is to explore how HR is regulated and how it interfaces with chromatin structure and the spatial organization of the genome. We employ cutting-edge technologies including high-throughput single-molecule sequencing and advanced imaging approaches. The project is carried in close collaboration between our genome analysis team, the bioinformatics/sequencing/genomics platforms of Institut Curie, and the teams of V. Bord (I. Curie, Paris) and G. Legube (LBCMCP, Toulouse) the worldwide experimental biologist experts in DNA recombination and DNA repair.
The ideal candidate should hold a Master/Engineer diploma with strong computational skills, a solid understanding of genome biology, and a keen interest in molecular mechanisms of DNA replication and repair. Experience in third-generation sequencing data (e.g. Nanopore and high-throughput imaging datasets are highly desired.
You will contribute to the development and application of pipelines and computational models to analyze complex genomic and imaging data. This position offers a unique opportunity to work at the interface of biology and data science, in a dynamic environment tackling fundamental questions in genome stability.
Constraints and risks:
* Occasional travel: to attend project meetings, workshops, or conferences with collaborators.
* Prolonged sitting:Ergonomic accommodation can be arranged to mitigate discomfort.
Training and Skills required
Code d'emploi : Ingénieur en Bioinformatique (h/f)
Domaine professionnel actuel : Biologistes
Niveau de formation : Bac+5
Temps partiel / Temps plein : Plein temps
Type de contrat : Contrat à durée déterminée (CDD)
Compétences : Analyse des Données, Bio-Informatique, Simulation Informatique, Linux, Perl (Programming Language), R (Langage de Programmation), Python (Langage de Programmation), High Performance Computing, Anglais, Sens de la Communication, Enthousiasme, Esprit d'Équipe, Motivation Personnelle, Curiosité, Biologie Molleculaire, Biologie, Neurodégénération, Chromatine, Ergonomie, Organisation d'Événements, Génomique, Oncologie, Recherche Scientifique, Etudes et Statistiques, Langue de Travail, Imagerie, Technologie de l'ADN Recombinant, Science des Données
Courriel :
job-ref-l2y8cb70r7@emploi.beetween.com
Téléphone :
0156245500
Type d'annonceur : Employeur direct